Bahrain's Sheikh Salman bin Ebrahim al-Khalifa has been backed to become the new Fifa president by the Confederation of African Football (CAF).
Sheikh Salman, the Asian Football Confederation president, is one of five candidates in the 26 February election.
After failing to receive the support of his own confederation, South African Tokyo Sexwale has been advised to "discontinue his campaign".
Meanwhile, the Spanish Football Federation has backed Gianni Infantino.
France's former Fifa deputy general secretary Jerome Champagne, Switzerland's Uefa general secretary Infantino, Sheikh Salman and Sexwale made presentations to CAF at a meeting in Rwanda on Friday, but the final candidate Prince Ali Bin Hussein of Jordan was not present.
Africa's football governing body has 54 full voting members in the poll to replace outgoing Fifa president Sepp Blatter, although their support does not necessarily translate into a united block of votes in the secret ballot.
CAF's decision is a blow to Sexwale and BBC Sport has been told by a senior South African Football Association official that the 62-year-old should end his campaign.
Sheikh Salman already has the backing of the Asian confederation, while Infantino is supported by the European body along with the 10-member South American confederation, CONMEBOL.
Sheikh Salman said: "The two endorsements only mean that there is a strong groundswell in favour of my candidacy. What they don't mean, is that I can sit back and relax.
"Naturally, I am confident that I now have a reasonably strong position to work from with such support."