Batsman Ian Bell has been dropped from England's Test squad for the tour of South Africa, which starts in December.
The five-time Ashes winner, 33, who has played 118 Tests, has not scored a century in 23 innings.
Batsmen Nick Compton and Gary Ballance are recalled, uncapped pace bowler Mark Footitt and spinner Samit Patel are included and Adil Rashid is left out.
Bell, 33, said he was "absolutely gutted" to miss out, but is "determined" to win his place back.
The tour begins on 15 December, with the first Test on 26 December.
England, who start with a warm-up game against a South African Invitational XI, will play four Tests, five one-day internationals and two Twenty20s.
South Africa are the top-ranked Test side in the world.